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Updated: Jul 10, 2026
09:30
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
Genotyping and genomic sequencing in clinical practice
Robert G Gish1, Stephen Locarnini
1California Pacific Medical Center, 2340 Clay St., Room 223, San Francisco, CA 94115, USA. gish@sutterhealth.org
Clinics in Liver Disease
|November 6, 2007
Summary
Nucleic acid testing (NAT) is crucial for managing chronic hepatitis B. This review highlights NAT's role in diagnosing, surveilling, and treating this global liver disease.
Area of Science:
- Hepatology
- Virology
- Molecular Diagnostics
Background:
- Chronic hepatitis B (CHB) poses a significant global health burden.
- CHB can lead to severe liver complications, necessitating advanced management strategies.
Purpose of the Study:
- To review the applications of nucleic acid testing (NAT) in CHB.
- To emphasize NAT's importance in the diagnosis and management of CHB.
Main Methods:
- Review of current literature on NAT techniques for hepatitis B virus (HBV).
- Discussion of quantitative PCR-based HBV DNA assays.
- Examination of HBV genotyping and mutation detection assays.
Main Results:
- NAT enables precise quantification of HBV DNA.
- NAT identifies HBV genotypes and antiviral resistance mutations.
- NAT detects key mutations like precore and core promoter variants.
Conclusions:
- NAT is indispensable for accurate CHB diagnosis and monitoring.
- NAT guides effective antiviral therapy selection and surveillance.
- Advanced NAT techniques improve CHB patient management outcomes.
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