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Related Experiment Video

Updated: Jul 10, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

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Published on: April 14, 2014

Acute demyelinating optic neuritis: a review.

Steven David Brass1, Robert Zivadinov, Rohit Bakshi

  • 1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Boston, MA, USA. sbrass@partners.org

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary

Acute demyelinating optic neuritis (ON) is a common cause of vision loss in young adults and often an early sign of multiple sclerosis (MS). Early MRI and disease-modifying therapies can help predict and reduce MS risk after ON.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Radiology

Background:

  • Acute demyelinating optic neuritis (ON) is a frequent cause of sudden, painful vision loss in young adults.
  • Multiple sclerosis (MS) is the most common underlying cause of ON, with ON being the first symptom in 15-20% of MS cases.

Purpose of the Study:

  • To explore the role of magnetic resonance imaging (MRI) in understanding ON pathophysiology and predicting MS risk.
  • To evaluate the impact of treatments on visual recovery and long-term MS development.

Main Methods:

  • Review of conventional and emerging MRI techniques for ON assessment.
  • Analysis of MS development rates based on brain lesion load (T2-weighted MRI) at 10 years post-ON.
  • Assessment of treatment effects of high-dose intravenous methylprednisolone and disease-modifying therapies.

Main Results:

  • Brain MRI lesion load at 10 years correlates with MS risk: 0 lesions (22%), 1 lesion (52%), 2+ lesions (56%).
  • High-dose intravenous methylprednisolone may speed visual recovery but doesn't alter long-term visual outcomes.
  • Disease-modifying therapies are effective in reducing future MS risk, especially when initiated early in patients with brain lesions.

Conclusions:

  • MRI is crucial for assessing ON and predicting MS risk.
  • Early intervention with disease-modifying therapies in ON patients with brain lesions can significantly lower the risk of developing MS.