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Updated: Jul 10, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Evoked potentials in acute ischemic stroke within the first 24 h: possible predictor of a malignant course
Lothar Burghaus1, Wei-Chi Liu, Christian Dohmen
1Department of Neurology, University of Cologne, Kerpener Str. 62, 50924 Cologne, Germany. lothar.burghaus@uk-koeln.de
Objective:
In patients with large middle cerebral artery (MCA) infarction, space-occupying brain edema may lead to a malignant course with up to 80% mortality, under conservative treatment. As interventional treatment strategies must be started before the deterioration occurs, predictors of a malignant course are necessary.
Material And Methods:
This study reports on the results of evoked potentials (brainstem auditory evoked potentials [BAEP] and median-nerve somatosensory evoked potentials [SEP]) within 24 h after onset of stroke in 30 patients suffering a large MCA infarct (14 patients with a malignant and 16 with a non-malignant course).
Results:
Our findings indicate that pathological BAEP indicate a malignant course (P < 0.05).
Conclusion:
This study shows that in patients suffering from large MCA infarction early assessment of EP within 24 h after onset of stroke may deliver useful information to select those patients who develop malignant edema.
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