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The relationship between Helicobacter pylori IgG titre and coronary atherosclerosis

Ibrahim Ozdogru1, Nihat Kalay, Ali Dogan

  • 1Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr

Acta Cardiologica
|November 7, 2007
PubMed

Insights

Helicobacter pylori (HP) IgG antibody levels are not linked to coronary artery disease presentation or inflammation. However, HP IgG titres may correlate with the extent of coronary atherosclerosis.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • The association between Helicobacter pylori (HP) infection and atherosclerosis remains debated.
  • Investigating HP's role in coronary artery disease (CAD) progression is crucial for understanding cardiovascular health.

Purpose of the Study:

  • To examine the relationship between Helicobacter pylori IgG antibody titers and the severity, extent, and clinical presentation of coronary atherosclerosis.
  • To assess if HP infection influences systemic inflammatory markers in CAD patients.

Main Methods:

  • A study involving 353 patients with confirmed CAD (myocardial infarction, unstable angina, stable angina) and 163 controls with normal coronary arteries.
  • Measurement of Helicobacter pylori IgG antibody titers using enzyme immunoassay.
  • Quantification of coronary atherosclerosis severity and extent using Gensini and Extent scores, respectively.
  • Assessment of C-reactive protein (CRP) levels as a marker of systemic inflammation.

Main Results:

  • Seropositivity rates for HP were similar in both CAD patients (82.7%) and controls (86.6%).
  • No significant differences in HP IgG levels were found among CAD subgroups (MI, USAP, SAP).
  • A weak but significant positive correlation was observed between HP IgG levels and the Extent score (atherosclerosis extent), but not the Gensini score (severity).
  • No correlation was found between CRP levels and HP IgG titers.

Conclusions:

  • Helicobacter pylori IgG antibody titers do not appear to be a significant factor in the clinical presentation of coronary artery disease.
  • HP infection does not seem to elevate systemic inflammatory response in the context of CAD.
  • HP IgG antibody titers may have a limited association with the extent of coronary atherosclerosis.
Abstract

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