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Updated: Jul 10, 2026

Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants
Published on: October 19, 2017
[Analytical application of phosphotungstic acid complexes. Synthesis and characterisation]
M Apostu1, V Dorneanu, Nela Bibire
1Facultatea de Farmacie, Disciplina de Chimie Analitică, Universitatea de Medicină si Farmacie "Gr.T. Pop" Iaşi.
Unlabelled:
Phosphotungstic acid forms salt type ionic association complexes with a large number of medicinal drugs that contain cation forming proton acceptor moieties.
Material And Method:
Ranitidine, nizatidine and famotidine complexes with phosphotungstic acid were synthesized and subsequently characterized by their melting point, water solubility, specific absorbance, UV spectra and IR spectra.
Results:
These sparingly soluble complexes were applied for the fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.
Conclusions:
There have been synthesized phosphotungstic acid complexes with uses in fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.
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