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05:31
Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
Published on: September 14, 2019
Six human cyclosporiasis: with general review.
Patrice Bourée1, Aurelia Lancon, Francine Bisaro
1Department of Parasitology, Bicetre Hospital, AP-HP, Paris XI University, France. patrice.bouree@bct.aphp.fr
Journal of the Egyptian Society of Parasitology
|November 8, 2007
Summary
Cyclospora cayetanensis causes cyclosporiasis, an emerging infectious diarrhea. Trimethoprim-sulfamethoxazole effectively treats this parasitic infection, often acquired through contaminated food or water during travel.
Area of Science:
- Medical Parasitology
- Infectious Diseases
- Epidemiology
Background:
- Cyclospora cayetanensis is an emerging coccidian parasite increasingly recognized as a human pathogen.
- While known in animals, its clinical significance in humans has become apparent in the last two decades.
- Cyclosporiasis presents diagnostic and therapeutic challenges, particularly in travelers returning from endemic regions.
Observation:
- A retrospective study analyzed 6 patients (24-67 years) presenting with diarrhea and weight loss post-travel.
- All patients were infected exclusively by Cyclospora cayetanensis after returning from Asian countries and Madagascar.
- Diarrhea was the predominant symptom, with transmission likely occurring via the oro-fecal route or contaminated food/water.
Findings:
- Diagnosis was confirmed by identifying Cyclospora cayetanensis in stool samples.
- Trimethoprim-sulfamethoxazole (TMZ) demonstrated high efficacy in treating cyclosporiasis.
- TMZ emerged as a preferred treatment, potentially supplanting Ciprofloxacin.
Implications:
- Cyclospora should be considered in unexplained prolonged diarrhea, especially in travelers with negative initial stool analyses.
- Effective prophylaxis involves controlling water supply and food safety measures.
- This study highlights the importance of recognizing and managing Cyclospora infections in clinical practice.
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