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Chronic myeloid leukemia associated with mitoxantrone treatment in a patient with MS
Saud A Sadiq1, Mustapha Rammal, Gabriel Sara
1Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, NY, USA. ssadiq@msrcny.org
Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 8, 2007
Abstract:
We report the first case of chronic myeloid leukemia (CML) in a patient with multiple sclerosis (MS) diagnosed within two years of receiving mitoxantrone therapy. Previously only acute forms of leukemia particularly acute promyelocytic leukemia (APL) have been associated with mitoxantrone treatment in MS. This underscores the need for only using mitoxantrone in severe treatment-unresponsive cases of MS.
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