Related Experiment Video
Updated: Jul 10, 2026

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
Published on: June 13, 2017
The thyrohyoid approach to in-office injection augmentation of the vocal fold
Daniel M Zeitler1, Milan R Amin
1Department of Otolaryngology-Head and Neck Surgery, New York University, New York, USA.
Purpose Of Review:
The purpose of this article is to review the history of vocal fold injection augmentation and provide a thorough description of the percutaneous thyrohyoid approach to office-based vocal fold injection augmentation for the management of glottic incompetence.
Recent Findings:
A number of techniques for vocal fold injection augmentation have been developed since the first procedure was performed. Since vocal fold injection augmentation is performed without an open surgical approach, morbidity is reduced and the technique can be done in the outpatient setting. Accordingly, over the past decade there has been an effort to perfect techniques and to develop new materials and methods to make the procedure more effective and comfortable for the patient.
Summary:
Recently, office-based vocal fold injection augmentation has gained significant popularity among laryngologists. While there are a variety of in-office injection techniques, the thyrohyoid approach, in the authors' opinion, is the simplest and best tolerated. This technique is effective and eliminates many of the shortcomings of the other approaches. This approach continues to be the 'workhorse' for in-office vocal fold injection augmentation in the senior author's practice. It is important, however, for any practitioner to be familiar with the other approaches, as this technique is not universally effective for all patients.
Related Concept Videos
The Hyoid Bone
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Suctioning the Oropharyngeal Airway
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
Larynx
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Muscles of the Anterior Neck
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...

