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Abnormal reward system activation in mania.

Birgit Abler1, Ian Greenhouse, Dost Ongur

  • 1Department of Psychiatry, University of Ulm, Germany. birgit.abler@uni-ulm.de

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|November 8, 2007
PubMed
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Dopamine system function differs in bipolar mania patients compared to controls during reward processing. This study reveals abnormal brain activation in manic patients, impacting reward prediction error signaling.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Dopamine neurotransmission is crucial for reward signaling and implicated in psychosis.
  • Altered dopamine function is hypothesized in psychotic disorders like schizophrenia and bipolar disorder.

Purpose of the Study:

  • To investigate how reward expectation and receipt modulate brain activation in patients with bipolar mania and schizophrenia.
  • To compare dopamine system function in response to monetary rewards between patient groups and healthy controls.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study brain activation.
  • A delayed incentive paradigm with monetary rewards was employed.
  • Participants included acutely manic bipolar patients, schizophrenia/schizoaffective patients, and healthy controls, all on dopamine antagonists.

Related Experiment Videos

Main Results:

  • Schizophrenia patients and healthy controls exhibited expected dopaminergic brain activation (ventral tegmentum, nucleus accumbens).
  • Manic patients showed no similar activation pattern.
  • Manic patients had significantly lower nucleus accumbens differential signal for reward receipt versus omission compared to controls.

Conclusions:

  • Findings suggest abnormal dopamine system function during reward receipt or omission in bipolar disorder.
  • Deficits in prediction error processing in acute mania may contribute to disinhibition and abnormal goal pursuit.