Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metallo-intercalators and metallo-insertors.

Brian M Zeglis1, Valerie C Pierre, Jacqueline K Barton

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125, USA.

Chemical Communications (Cambridge, England)
|November 9, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linker Chemistry in Radiopharmaceutical Design.

Bioconjugate chemistry·2026
Same author

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic.

Angewandte Chemie (International ed. in English)·2026
Same author

Efficacy of CLDN18.2-Targeted Radiotheranostics in Patient-Derived Models of Gastric Cancer.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Pharmacokinetic Optimization of Radiocopper-Based Theranostic Pretargeting.

Molecular pharmaceutics·2026
Same author

Harnessing Frémy's salt for tyrosine-directed bioconjugations.

RSC advances·2026
Same author

Selective Bicarbonate Receptors for Direct Ocean Capture of CO<sub>2</sub>.

JACS Au·2025
Same journal

An intrinsically stretchable nanowire-based sensing patch for wearable analysis of sweat chloride ion composition.

Chemical communications (Cambridge, England)·2026
Same journal

A sterically rigid-flexible balanced NHC-Pd precatalyst for room-temperature solvent-free C-N coupling of benzocyclic amines.

Chemical communications (Cambridge, England)·2026
Same journal

Portable fluorescent conjugated microporous polymer sensor coupled with a smartphone for on-site Fe<sup>3+</sup> detection in water.

Chemical communications (Cambridge, England)·2026
Same journal

Accelerated discovery of NO<sub>3</sub>RR single-atom catalysts <i>via</i> high-throughput DFT and machine learning.

Chemical communications (Cambridge, England)·2026
Same journal

Wafer-scale robust graphene electronics under industrial processing conditions.

Chemical communications (Cambridge, England)·2026
Same journal

Subnanoscale IrW oxide anodes: breaking immiscibility for high activity and durability in water electrolysis.

Chemical communications (Cambridge, England)·2026
See all related articles

Researchers designed octahedral metal complexes for specific DNA targeting. These complexes non-covalently bind DNA and can be used for various applications, including targeting single base mismatches.

Area of Science:

  • Coordination Chemistry
  • Molecular Biology
  • Biophysical Chemistry

Background:

  • The structure of double helical DNA has spurred interest in small molecules for specific DNA recognition and reaction.
  • Transition metal complexes offer unique photophysical properties and modular assembly for DNA binding applications.

Purpose of the Study:

  • To review recent experiments on the design and study of octahedral metal complexes for DNA binding.
  • To highlight methods for conferring site-specificity and applications of these complexes.

Main Methods:

  • Design and synthesis of octahedral metal complexes.
  • Investigation of non-covalent DNA binding mechanisms.
  • Development of site-specific DNA targeting strategies.
  • Exploration of metallo-insertion for targeting DNA base mismatches.

Related Experiment Videos

Main Results:

  • Demonstrated the ability of octahedral metal complexes to bind DNA non-covalently.
  • Developed diverse methods to achieve site-specific DNA targeting.
  • Showcased applications of these metal complexes in DNA research.
  • Highlighted a novel family of complexes targeting single base mismatches via metallo-insertion.

Conclusions:

  • Octahedral metal complexes are versatile tools for specific DNA recognition and reaction.
  • Metallo-insertion offers a promising strategy for targeting DNA base mismatches.
  • These complexes have broad applications in molecular biology and medicinal chemistry.