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Deep vein thrombosis--a rare post transplant complication
Tariq Muhammad Satti1, Khalil Ullah, Parvez Ahmed
1Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan.
JPMA. the Journal of the Pakistan Medical Association
|November 10, 2007
Summary
Deep vein thrombosis (DVT) is a rare complication after stem cell transplant (SCT). Careful monitoring of anticoagulation therapy is crucial to prevent fatal bleeding events in high-risk patients.
Area of Science:
- Transplantation Medicine
- Hematology
- Vascular Medicine
Background:
- Deep vein thrombosis (DVT) is a rare but serious condition that can occur after organ or stem cell transplantation.
- It often results from a combination of risk factors, including venous stasis, making diagnosis and management critical.
Observation:
- A 7-year-old boy with B-thalassaemia major developed DVT four months post-SCT.
- He was treated with anticoagulants, including low molecular weight heparin and warfarin sodium, with INR stabilized between 2.5-3.0.
Findings:
- Despite therapeutic anticoagulation, the patient later presented with bleeding diathesis.
- The patient died due to intracranial hemorrhage, attributed to excessive and unchecked anticoagulation.
Implications:
- This case highlights the critical need for strict monitoring of anticoagulation therapy in post-transplant patients.
- Close monitoring of PT/INR is essential to prevent potentially fatal bleeding complications from over-anticoagulation.
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