Contemplating the future without Helicobacter pylori and the dire consequences hypothesis

Area of Science:

• Microbiology
• Infectious Diseases
• Public Health

Background:

• Helicobacter pylori (H. pylori) is a globally prevalent, transmissible pathogen responsible for substantial gastric disease, morbidity, and mortality.
• The long evolutionary association between H. pylori and humans has led to hypotheses suggesting potential benefits and adverse outcomes following its eradication.
• Historical and treatment data now provide a robust basis for evaluating the impact of H. pylori infection.

Purpose of the Study:

• To critically evaluate the role of Helicobacter pylori as a pathogen.
• To address the hypothesis that H. pylori eradication has negative consequences.
• To advocate for the global eradication of H. pylori.

Main Methods:

• Review of existing scientific literature on H. pylori's impact.
• Analysis of outcomes from H. pylori treatment regimens.
• Examination of populations with historical absence of H. pylori infection.

Main Results:

• H. pylori causes significant gastric damage, contributing to worldwide morbidity and mortality.
• Hypotheses regarding benefits of H. pylori and dire consequences of eradication are not supported by current evidence.
• The pathogen is a significant source of suffering and disease, with no discernible benefit to humans.

Conclusions:

• Helicobacter pylori is a detrimental pathogen that offers no benefits and should be eradicated.
• Claims of negative consequences from H. pylori eradication are unfounded.
• Eradication of H. pylori is a necessary public health goal, akin to eliminating smallpox and polio.