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miRBase: tools for microRNA genomics.

Sam Griffiths-Jones1, Harpreet Kaur Saini, Stijn van Dongen

  • 1Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK. sam.griffiths-jones@manchester.ac.uk

Nucleic Acids Research
|November 10, 2007
PubMed
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This summary is machine-generated.

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miRBase is a key database for microRNA (miRNA) information, offering sequence data and genomic mapping. The latest release significantly expands miRNA sequence and annotation data across multiple species.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression.
  • Centralized repositories are essential for managing and accessing miRNA data.
  • miRBase serves as the primary resource for miRNA nomenclature, sequence, and annotation.

Purpose of the Study:

  • To present the latest release of the miRBase database.
  • To highlight new features and data content relevant to miRNA research.
  • To facilitate genomic studies of miRNAs.

Main Methods:

  • Data compilation from various species.
  • Genomic mapping of miRNA loci.
  • Annotation of miRNA sequence overlap with transcripts.
  • Development of graphical views for miRNA primary transcript prediction.

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Main Results:

  • Release 10.0 contains 5071 miRNA loci from 58 species, yielding 5922 mature miRNA sequences.
  • Significant growth in sequence data (over 2000 new sequences in 2 years).
  • Genomic coordinates, clusters, and overlap with annotated transcripts are provided.
  • Graphical views enable prediction of miRNA primary transcript boundaries.

Conclusions:

  • miRBase continues to be an indispensable resource for miRNA research.
  • The expanded dataset and new features enhance the study of miRNA genomics.
  • miRBase supports diverse research applications from sequence analysis to gene regulation studies.