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Peripheral blood eosinophilia in atopic dermatitis
Dorota Jenerowicz1, Magdalena Czarnecka-Operacz, Wojciech Silny
1Department of Dermatology and Allergic Diseases Diagnostic Center, University of Medical Sciences, Przybyszewski Str. 49, 60-355 Poznañ, Poland. djen@poczta.onet.pl
Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|November 10, 2007
Summary
Peripheral blood eosinophilia is significantly higher in patients with atopic dermatitis (AD). This elevated eosinophil count may help differentiate allergic AD from non-allergic forms, aiding in diagnosis.
Area of Science:
- Dermatology
- Immunology
- Allergology
Background:
- Eosinophils and their proteins accumulate in atopic dermatitis (AD) skin lesions.
- Increased Th2 activity in acute AD correlates with IL-5, promoting eosinophil production and activation.
Purpose of the Study:
- To investigate the role of eosinophils in the pathogenesis of AD.
- To evaluate peripheral blood eosinophilia as a diagnostic marker for AD.
Main Methods:
- Examined 30 AD patients, 30 chronic urticaria patients, and 30 healthy controls.
- Measured peripheral blood eosinophil counts (percentage and absolute number).
- Assessed serum antigen-specific IgE (asIgE) using CAP System FEIA.
Main Results:
- AD patients showed significantly higher peripheral blood eosinophil counts (290.0 +/- 205.7/mm3) compared to controls (113.3 +/- 93.7 and 153.3 +/- 113.7/mm3).
- Severe AD cases exhibited higher eosinophilia than mild/moderate cases, though not statistically significant.
- Peripheral blood eosinophilia was more pronounced in AD patients with positive skin prick tests (SPT), detectable asIgE, or other atopic conditions.
Conclusions:
- Eosinophils play a significant role in the etiopathogenesis of AD.
- Peripheral blood eosinophilia can potentially serve as a diagnostic parameter to distinguish between allergic and non-allergic AD.
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