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Working memory in obstructive sleep apnea: construct validity and treatment effects.

Joshua C Felver-Gant¹, Amanda S Bruce, Molly Zimmerman

¹Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine

|November 13, 2007

Summary

This summary is machine-generated.

Obstructive sleep apnea (OSA) impairs working memory. Positive airway pressure (PAP) treatment improved working memory performance in high-adherence patients, suggesting working memory is sensitive to OSA treatment.

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Area of Science:

Neuroscience
Sleep Medicine
Cognitive Psychology

Background:

Obstructive sleep apnea (OSA) is linked to cognitive deficits.
Working memory is crucial for daily functioning and may be affected by OSA.

Purpose of the Study:

To validate the 2-Back task for assessing working memory in OSA patients.
To determine the impact of positive airway pressure (PAP) treatment on working memory and its components in OSA.

Main Methods:

Fifty-six OSA participants underwent cognitive testing before and after 3 months of PAP treatment.
PAP adherence was objectively monitored.
Statistical analyses examined changes in cognitive performance over time.

Main Results:

The 2-Back task showed construct validity, correlating with other working memory and cognitive measures.
High PAP adherence (≥4 hours/night) was associated with significant improvements in working memory (2-Back and PASAT).
Low PAP adherence did not yield cognitive improvements; no effects were seen on other cognitive measures.

Conclusions:

The 2-Back task is a valid measure of working memory in OSA.
Working memory is a sensitive cognitive domain affected by OSA and responsive to PAP treatment adherence.