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Published on: June 20, 2012
Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage
Olaf Dammann1, Wolfgang Bueter, Alan Leviton
1Division of Newborn Medicine, Department of Pediatrics, Tufts-New England Medical Center, Boston, Mass., USA. odammann@tufts-nemc.org
Abstract:
Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention.
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