Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supramolecular Effects of Alkyl Sulfonates in Silver Nanocrystal Synthesis.

ACS nanoscience Au·2026
Same author

A Simple Single-Pot, Heat-Up Reaction for Uniform Hexagonal CuInS<sub>2</sub> Nanoplatelets and the Role of Disubstituted Thiourea Chain Length in Their Growth.

ACS omega·2025
Same author

The Primarily Undergraduate Nanomaterials Cooperative: A New Model for Supporting Collaborative Research at Small Institutions on a National Scale.

ACS nanoscience Au·2023
Same author

Self-adaptive amplified spontaneous emission suppression with a photorefractive two-beam coupling filter.

Optics letters·2020
Same author

Experimental Demonstration of Shaken-Lattice Interferometry.

Physical review letters·2018
Same author

Synthesis and characterization of AgGaS<sub>2</sub> nanoparticles: a study of growth and fluorescence.

Chemical communications (Cambridge, England)·2017

Related Experiment Video

Updated: Jul 10, 2026

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects
10:16

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Published on: February 8, 2014

Modulation-enhanced sensitivity of holographic interferometry.

Steven M Hughes1, Dana Z Anderson

  • 1Department of Electrical and Computer Engineering, University of Colorado, 440 UCB, Boulder, Colorado 80309-0440, USA.

Applied Optics
|November 13, 2007
PubMed
Summary
This summary is machine-generated.

A new modulation-demodulation technique significantly boosts adaptive interferometric sensitivity. This method improves displacement sensitivity by converting quadratic signals to linear, overcoming system noise and enhancing low-frequency measurements.

More Related Videos

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
10:28

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy
10:09

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Jul 10, 2026

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects
10:16

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Published on: February 8, 2014

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
10:28

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy
10:09

Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic Microscopy

Published on: September 16, 2022

Area of Science:

  • Optical interferometry
  • Precision measurement science

Background:

  • Adaptive interferometry is crucial for sensitive measurements.
  • System noise and 1/f noise limit sensitivity in diffusion-dominated systems.
  • Quadratic small-signal responses are difficult to detect amidst noise.

Purpose of the Study:

  • To enhance the sensitivity of diffusion-dominated adaptive interferometry.
  • To overcome limitations imposed by system noise and low-frequency noise (1/f noise).
  • To convert quadratic responses to a more detectable linear form.

Main Methods:

  • Implementing a novel modulation-demodulation scheme.
  • Utilizing strong phase modulation to mix with the signal.
  • Converting the quadratic small-signal response to a linear response.
  • Shifting low-frequency signals away from the 1/f noise spectrum.

Main Results:

  • Achieved 180 fm/√Hz displacement sensitivity for a 5 Hz signal.
  • Demonstrated a 3-orders-of-magnitude improvement over unenhanced systems.
  • Showcased the effectiveness of the modulation-demodulation technique at low optical power (milliwatts).

Conclusions:

  • The developed modulation-demodulation scheme substantially enhances adaptive interferometric sensitivity.
  • This technique effectively mitigates system noise and 1/f noise limitations.
  • The method offers a significant advancement for precision displacement measurements.