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Tardive gait.

Sheng-Han Kuo1, Joseph Jankovic

  • 1Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, United States.

Clinical Neurology and Neurosurgery
|November 13, 2007
PubMed
Summary
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Tardive dyskinesia (TD), a movement disorder from dopamine receptor blocking drugs, may include gait abnormalities. This study identifies "tardive gait" as a potential symptom within the TD spectrum.

Area of Science:

  • Neurology
  • Movement Disorders
  • Pharmacology

Background:

  • Tardive dyskinesia (TD) is a neurological disorder characterized by involuntary movements.
  • It is primarily caused by dopamine receptor blocking drugs (DRBDs).
  • Common TD symptoms include stereotypy, dystonia, akathisia, myoclonus, and tremor.

Observation:

  • Gait abnormalities have not been well-documented in existing literature on TD.
  • This report details three cases of patients exposed to DRBDs who developed distinct gait disturbances.
  • These patients exhibited symptoms suggestive of a novel presentation termed "tardive gait".

Findings:

  • The observed gait dysfunction in these patients appears to be linked to DRBD exposure.
  • The characteristics of "tardive gait" suggest it is a specific manifestation of TD.

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  • This expands the known clinical spectrum of tardive dyskinesia.

    • Implications:

    • Recognizing gait dysfunction as part of TD is crucial for accurate diagnosis.
    • This finding may prompt further research into the pathophysiology of TD-related gait issues.
    • Clinicians should consider evaluating gait in patients with suspected or confirmed TD.