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A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation
N G Huilgol1, C K K Nair, P Merhotra
1Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai, India. nagrajh@vsnl.net
Purpose:
To evaluate Tocoferol monoglucoside (TMG), a water soluble vit. E. in a phase I trial, as a radiation protector in those undergoing hemi-body radiation for disseminated disease.
Materials And Methods:
Patients scheduled to receive modified hemi-body radiation were accrued for the study. Patients not only had disseminated skeletal disease but, were heavily pretreated Seven patients were accrued for the study. Patients received 1 and 2 gms of TMG. 30-40 minutes before hemibody radiation. A dose of 600 cGy was delivered on telecobalt equipment at mid plane. Immediate Toxicities were evaluated as well as response to pain.
Results:
All the seven patients underwent radiation uneventfully. There was no drug related toxicity. Pain relief was adequate.
Conclusion:
Tocoferol monoglucoside an effective antioxidant with no significant acute toxicity, when administered in a dose of 1 or 2 gms per oral route. TMG being water-soluble can have global antioxidant and radio protective effects. This needs further clinical evaluation.
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