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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 10, 2026

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Brain metastasis--evidence based management.

G Biswas1, R Bhagwat, R Khurana

  • 1Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai-400 012, India.

Journal of Cancer Research and Therapeutics
|November 14, 2007
PubMed
Summary

Increased cancer survival leads to more brain metastases. Management involves advanced imaging, surgery, radiotherapy, and emerging chemotherapy agents like temozolomide for better patient outcomes.

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Last Updated: Jul 10, 2026

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
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Area of Science:

  • Oncology
  • Neurology
  • Radiotherapy

Background:

  • Cancer survival rates have significantly improved due to advances in treatment.
  • An increasing number of cancer patients are developing symptomatic brain metastases.
  • Effective management strategies for brain metastases are crucial for improving quality of life.

Purpose of the Study:

  • To discuss the current management of symptomatic brain metastases.
  • To highlight the role of diagnostic imaging and various treatment modalities.
  • To explore the potential of new chemotherapeutic agents in treating brain metastases.

Main Methods:

  • Contrast-enhanced MRI scan of the brain is the definitive diagnostic investigation.
  • Management approaches include supportive care and disease-directed treatments.
  • Surgical resection, whole brain radiotherapy, and chemotherapy are key treatment options.

Main Results:

  • Surgical resection is the gold standard for solitary brain metastases.
  • Whole brain radiotherapy is a standard treatment for all patients.
  • Emerging chemotherapeutic agents like temozolomide and topotecan show antitumor activity.

Conclusions:

  • Multimodality treatment aims to palliate local symptoms and prevent neurological deficits.
  • New chemotherapeutic agents offer promising options for systemic and brain metastasis treatment.
  • Comprehensive management is essential for improving the prognosis of patients with brain metastases.