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Updated: Jul 10, 2026

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
[Fetal bladder development. A current overview]
1European Academy of Pediatric Urology, Abteilung für Kinderurologie der Universität Regensburg, Klinik St. Hedwig, Steinmetzstrasse 1-3, Regensburg, Germany. iris.koerner@barmherzige-regensburg.de
Abstract:
Human fetal bladder development starts in the 9th to 10th week of gestation. Smooth muscle cell formation is induced by Hedgehog proteins and their signaling in the surrounding mesenchyma of the fetal bladder cavity. Bladder wall thickness increases significantly with advancing gestation, mediated by linear growth patterns irrespective of the related sex. lt is the aim of this article to address new insights into bladder development to enhance our knowledge about normal and pathological conditions that occur when developmental processes are disturbed.
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