[Treatment of vesicoureteral reflux in childhood]

Area of Science:

• Pediatric Urology
• Nephrology
• Surgical Innovation

Background:

• Vesicoureteral reflux (VUR) pathophysiology and treatment require ongoing critical evaluation.
• Recent clinical studies and basic research have advanced understanding of VUR.
• A spectrum of therapeutic options exists for VUR management.

Purpose of the Study:

• To critically revise the understanding and therapeutic spectrum of vesicoureteral reflux.
• To prospectively analyze three different treatment options for dilated VUR in small children.
• To provide a statement on open operative reflux therapy in conjunction with study findings.

Main Methods:

• Prospective randomized analysis of antibiotic prophylaxis, endoscopic reflux correction, and surveillance.
• Inclusion of small children with dilated vesicoureteral reflux.
• Discussion of results and comparison with open operative reflux therapy.

Main Results:

• The Swedish Reflux Study prospectively compared three VUR treatment strategies.
• Antibiotic prophylaxis, endoscopic correction, and surveillance outcomes were analyzed.
• Results inform the critical revision of VUR therapeutic approaches.

Conclusions:

• Findings necessitate a critical revision of current vesicoureteral reflux management strategies.
• The study provides evidence-based insights into VUR treatment efficacy.
• Recommendations are made regarding antibiotic prophylaxis, endoscopic correction, and surveillance for VUR.