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Antifungal activity of fumaric acid in mice infected with Candida albicans

M Akao1, K Kuroda

  • 1Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.

Chemical & Pharmaceutical Bulletin
|November 1, 1991
PubMed

Insights

Fumaric acid treatment prolonged survival in mice with systemic candidiasis. This antifungal compound prevented mortality in a significant portion of the challenged animals.

Area of Science:

  • Mycology
  • Pharmacology
  • Immunology

Background:

  • Systemic candidiasis poses a significant threat, often requiring effective therapeutic interventions.
  • Candida albicans is a common opportunistic fungal pathogen responsible for candidiasis.

Purpose of the Study:

  • To investigate the therapeutic potential of fumaric acid against experimental systemic candidiasis.
  • To evaluate the impact of fumaric acid on survival rates in a murine model of fungal infection.

Main Methods:

  • Male ICR mice were intravenously inoculated with Candida albicans yeast cells.
  • Fumaric acid was administered daily via intraperitoneal injections at a dosage of 40 mg/kg/day.

Main Results:

  • Fumaric acid administration significantly prolonged the survival time of mice challenged with Candida albicans.
  • The treatment demonstrated a protective effect, preventing death in approximately 20% of the treated animals.

Conclusions:

  • Fumaric acid exhibits notable efficacy in managing experimental systemic candidiasis.
  • Fumaric acid represents a promising therapeutic agent for combating Candida albicans infections.

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