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Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

Cytoskeletal Coordination in Cell Migration

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

Cancer Cell Migration through Invadopodia

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

Chemotaxis and Direction of Cell Migration

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

Role of Myosin in Cell Migration

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Related Experiment Video

Updated: Jul 10, 2026

In vitro Cell Migration and Invasion Assays

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Recap on cell migration.

Mark S Bretscher¹

¹Division of Cell Biology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. msb@mrc-lmb.cam.ac.uk

Traffic (Copenhagen, Denmark)

|November 15, 2007

Summary

Animal cells exhibit a phenomenon called capping, where surface antigens move to one pole. This process, crucial for cell movement, remains poorly understood despite its accessibility.

Area of Science:

Cell biology
Biophysics

Background:

Most animal cells exhibit capping, the movement of surface antigens to a cellular pole.
This phenomenon is linked to particle movement on cell surfaces and cell motility.
The underlying mechanisms of cap formation are currently unknown.

Purpose of the Study:

To investigate the unknown mechanisms driving cap formation in animal cells.
To elucidate the relationship between capping and cell movement dynamics.

Main Methods:

This study focuses on observing and analyzing the dynamic properties of cell capping.
Methods likely involve advanced microscopy and cell tracking techniques (details not provided in abstract).

Main Results:

The abstract does not contain specific results.

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Last Updated: Jul 10, 2026

In vitro Cell Migration and Invasion Assays

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Study of Cell Migration in Microfabricated Channels

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

Further research is needed to determine the outcomes of the proposed investigation.

Conclusions:

Cap formation is a key dynamic cellular process.
Understanding capping is essential for comprehending cell movement.
Further investigation is required to uncover the mechanisms of capping.