Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The BioGRID Interaction Database: 2008 update.

Bobby-Joe Breitkreutz1, Chris Stark, Teresa Reguly

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

Nucleic Acids Research
|November 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extending Biopython to combine multiple sequence alignments with the same reference into a Multiple Sequence Alignment.

microPublication biology·2026
Same author

Genetic and environmental determinants of multicellular-like phenotypes in fission yeast.

Genetics·2026
Same author

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

bioRxiv : the preprint server for biology·2026
Same author

PomBase in 2026: expanding knowledge, modeling connections.

Genetics·2026
Same author

Mitochondrial Translation Inhibition Triggers an Rst2-Controlled Transcriptional Reprogramming of Carbon Metabolism in Stationary-Phase Cells of Fission Yeast.

Biomolecules·2025
Same author

The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in <i>Schizosaccharomyces pombe</i>.

Biomolecules·2025
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

The Biological General Repository for Interaction Datasets (BioGRID) database now offers a comprehensive collection of protein and genetic interactions for model organisms. This resource is continuously updated and freely available, aiding biological research.

Area of Science:

  • * Molecular Biology
  • * Systems Biology
  • * Bioinformatics

Background:

  • * The Biological General Repository for Interaction Datasets (BioGRID) was established to centralize protein and genetic interaction data.
  • * Existing data repositories often lacked comprehensive coverage or user-friendly access.

Purpose of the Study:

  • * To create a centralized, comprehensive, and accessible database of protein and genetic interactions.
  • * To support biological research by providing curated interaction data for model organisms.

Main Methods:

  • * Comprehensive literature curation of high-throughput and focused studies.
  • * Data integration from primary research articles.
  • * Development of an improved user interface and data management system.

Related Experiment Videos

Main Results:

  • * BioGRID houses over 198,000 interactions across six species.
  • * Virtually complete interaction data for Saccharomyces cerevisiae and Schizosaccharomyces pombe.
  • * New features include an improved interface, mirror site, and interaction management system.

Conclusions:

  • * BioGRID is a valuable, up-to-date resource for protein and genetic interaction data.
  • * The database facilitates research in model organisms through accessible and comprehensive data.
  • * Freely available source code promotes further development and integration.