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Updated: Jul 10, 2026
04:33
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
Published on: March 12, 2019
Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial
Eleanor M Gurnell1, Penelope J Hunt, Suzanne E Curran
1Department of Public Health and Primary Care, Centre for Applied Medical Statistics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
The Journal of Clinical Endocrinology and Metabolism
|November 15, 2007
Summary
Dehydroepiandrosterone (DHEA) supplementation improved bone density and lean mass in Addison's disease patients. While not affecting fatigue or cognition, DHEA positively impacted psychological well-being.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Bone Health
Background:
- Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are key adrenal steroids.
- Addison's disease involves glucocorticoid/mineralocorticoid deficiency and impaired DHEA synthesis.
- Current treatments for Addison's disease do not typically address DHEA deficiency.
Purpose of the Study:
- To evaluate the long-term effects of DHEA supplementation in Addison's disease.
- Assessed impacts on bone mineral density, body composition, and cognitive function.
- Investigated effects on well-being and fatigue.
Main Methods:
- A 12-month, double-blind, placebo-controlled trial.
- 106 participants with Addison's disease received 50 mg daily of micronized DHEA or placebo.
- Evaluated bone density, body composition, cognitive function, well-being, and fatigue.
Main Results:
- DHEA increased circulating DHEAS and androstenedione; testosterone normalized in females.
- DHEA reversed bone loss at the femoral neck and increased lean mass.
- Psychological well-being improved, but fatigue, cognition, and sexual function showed no significant change.
- Mild androgenic side effects occurred in some older females.
Conclusions:
- Prolonged DHEA treatment shows some beneficial effects in Addison's disease.
- Further studies with dosage adjustments are warranted.
- DHEA may help improve bone health and body composition in these patients.
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