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Updated: Jul 10, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Molecular cytogenetics in the study of cutaneous T-cell lymphomas (CTCL)
L Karenko1, S Hahtola, A Ranki
1Department of Dermatology and Venereology, The University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. leena.p.karenko@hus.fi
Abstract:
The etiology of primary cutaneous T-cell lymphomas (CTCL) has been poorly understood. CTCL patients show a large variety of non-clonal and clonal chromosome aberrations, but no specific aberration has been found until recently. This review describes cytogenetic and molecular cytogenetic findings and their relevance to diagnostics and etiology in two of the most common forms of CTCL, mycosis fungoides (MF) and the leukemic CTCL, Sézary syndrome (SS).

