Related Experiment Video
Updated: Jul 10, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
[Chronic relapsing inflammatory optic neuropathy (CRION) without detection of IgG-NMO antibodies]
H Pérez-Díaz1, J L Casado, A Uclés-Sánchez
1Servicio de Neurología, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. hperezdiaz@yahoo.es
Abstract:
Chronic relapsing inflammatory optic neuropathy is a disease that should be distinguished from demyelinating optic neuropathy (ON). Long-term immunosuppressive therapy is usually necessary and either an inflammatory granulomatous origin or a relationship with neuromyelitis optica (NMO) is hypothesized. We report a 43-year-old man who suffered from several ON episodes affecting one eye or the other. These ON attacks completely disappeared with steroid therapy but relapsed after its withdrawal. IgG-NMO antibodies were negative.
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