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Vibration effects on dissolution tests with USP apparatuses 1 and 2

Zongming Gao1, Terry W Moore, William H Doub

  • 1Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101, USA. zongming.gao@fda.hhs.gov

Journal of Pharmaceutical Sciences
|November 15, 2007
PubMed
Summary

Environmental vibration significantly impacts drug dissolution testing, especially for disintegrating tablets using USP Apparatuses 1 and 2. Nondisintegrating tablets showed increased variability but not sensitivity to vibration.

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