Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid-phase olefin cross-metathesis promoted by a linker.

Amanda L Garner1, Kazunori Koide

  • 1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.

Organic Letters
|November 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SHAPE-Based Chemical Probes for Studying preQ<sub>1</sub>-RNA Interactions in Living Bacteria.

ACS chemical biology·2025
Same author

SHAPE-based chemical probes for studying preQ<sub>1</sub>-RNA interactions in living bacteria.

bioRxiv : the preprint server for biology·2025
Same author

CRISPR RiPCA for Investigating eIF4E-m<sup>7</sup>GpppX Capped mRNA Interactions.

ACS chemical biology·2025
Same author

CRISPR RiPCA for Investigating eIF4E-m<sup>7</sup>GpppX Capped mRNA Interactions.

bioRxiv : the preprint server for biology·2025
Same author

Chemical Probes for Studying the Eukaryotic Translation Initiation Factor 4E (eIF4E)-Regulated Translatome in Cancer.

ACS pharmacology & translational science·2025
Same author

Atmosphere Effects on Arene Reduction with Lithium and Ethylenediamine in THF.

The Journal of organic chemistry·2025
Same journal

Organophosphine-Promoted Decarbynylative Hydrocarbenylation of the Carbon-Carbon Triple Bond.

Organic letters·2026
Same journal

Total Syntheses of BE-54238A and -B.

Organic letters·2026
Same journal

Visible Light-Induced <i>N</i>-Phenylbenzo[<i>c</i>]phenothiazine-Catalyzed α-C(sp<sup>3</sup>)-H Phosphonylation of Secondary Amines via Intramolecular 1,5-HAT.

Organic letters·2026
Same journal

Cobalt-Stabilized Propargylic Oxocarbenium Ions Enable Direct and Asymmetric Nickel(II) Catalyzed Aldol-Like Reactions.

Organic letters·2026
Same journal

Photoinduced Regioselective Sulfonylation/Cyclization of <i>N</i>-Cinnamylenamides toward Sulfonylated Tetrahydropyridines via Catalytic Electron Donor-Acceptor Complexes.

Organic letters·2026
Same journal

Amine-Enabled Electron Donor-Acceptor Complex Catalysis for Cyclopropanation.

Organic letters·2026
See all related articles

Olefin cross-metathesis is now viable for solid-phase synthesis. Using a traceless longer linker enables this powerful coupling method on solid supports for complex molecule construction.

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Polymer Chemistry

Background:

  • Olefin cross-metathesis is a key reaction for synthesizing complex organic molecules in solution.
  • Application of olefin cross-metathesis in solid-phase synthesis has been limited.
  • Solid-phase synthesis offers advantages in purification and automation.

Purpose of the Study:

  • To investigate the feasibility of olefin cross-metathesis for solid-phase organic synthesis.
  • To develop a method for effectively performing olefin cross-metathesis on solid supports.
  • To demonstrate the utility of this approach in constructing complex molecules.

Main Methods:

  • Development of a solid-phase strategy incorporating a traceless longer linker.
  • Attachment of olefins to the solid support via the specialized linker.

Related Experiment Videos

  • Execution of olefin cross-metathesis reactions directly on the solid support.

    • Main Results:

    • Olefin cross-metathesis was successfully performed on a solid support.
    • The use of a traceless longer linker was crucial for the reaction's success.
    • Complex molecules were synthesized efficiently using this solid-phase methodology.

    Conclusions:

    • Olefin cross-metathesis is a synthetically viable and powerful tool for solid-phase synthesis.
    • The developed method overcomes previous limitations, enabling broader application of this reaction.
    • This approach facilitates the synthesis of complex molecules with improved purification and automation potential.