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Gliclazide: a general free radical scavenger
N A Scott1, P E Jennings, J Brown
1University Department of Medicine, Ninewells Hospital and Medical School, Dundee, U.K.
European Journal of Pharmacology
|October 14, 1991
Summary
Gliclazide effectively scavenges free radicals in laboratory tests, unlike glibenclamide. This antioxidant property may play a role in managing diabetic complications.
Area of Science:
- Biochemistry
- Pharmacology
- Endocrinology
Background:
- Free radical damage is linked to diabetic microangiopathy.
- Antioxidant agents that neutralize free radicals may offer therapeutic benefits for diabetes.
Purpose of the Study:
- To evaluate the in vitro free radical scavenging activity of two sulfonylurea drugs: gliclazide and glibenclamide.
- To determine if gliclazide and glibenclamide possess antioxidant properties relevant to diabetes treatment.
Main Methods:
- An o-dianisidine assay sensitized by riboflavin was used to assess scavenging abilities.
- The assay distinguishes between superoxide scavengers (augmentation) and general scavengers (inhibition).
- Gliclazide and glibenclamide were tested at concentrations ranging from 0.5 to 5.0 µg/ml.
Main Results:
- Gliclazide demonstrated significant dose-dependent inhibition, indicating general free radical scavenging activity.
- Percentage inhibition for gliclazide ranged from 11.0% to 47.2% across tested concentrations.
- Glibenclamide exhibited no discernible free radical scavenging effects in this in vitro assay.
Conclusions:
- Gliclazide acts as a potent in vitro scavenger of general free radicals.
- The free radical scavenging capacity of gliclazide could be a significant factor in its therapeutic efficacy for diabetes.