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Updated: Jul 10, 2026
12:24
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
From bench-top small animal diffuse optical tomography towards clinical imaging
Anabela Da Silva1, Jean-Marc Dinten, Jean-Luc Coll
1CEA-LETI MINATEC, 17 rue des Martyrs, Grenoble Cedex 9, France. anabela.dasilva@cea.fr
Summary
Fluorescence enhanced diffuse optical tomography offers a non-invasive, accurate imaging tool. This technology aids in localizing and quantifying fluorescent probes, potentially replacing traditional radiation-based methods.
Area of Science:
- Biomedical optics
- Medical imaging
- Diagnostic technology
Background:
- Diffuse optical tomography (DOT) is an emerging diagnostic tool.
- Fluorescence enhanced DOT offers localization and quantification of fluorescent probes.
- It serves as a supplement or replacement for ionizing radiation imaging techniques.
Purpose of the Study:
- To develop simple, inexpensive, non-invasive, and accurate instrumentation for fluorescence enhanced DOT.
- To advance small animal imaging capabilities with novel markers and instrumentation.
- To enable specific examination of deeply embedded underlying structures for human screening.
Main Methods:
- Development of specialized instrumentation for fluorescence enhanced diffuse optical tomography.
- Application of knowledge in markers and instrumentation for small animal imaging.
- Focus on techniques for examining deep tissue structures.
Main Results:
- Established a knowledge base in markers and instrumentation over four years.
- Developed new instrumentation for enhanced tissue imaging.
- Paved the way for human screening applications.
Conclusions:
- Fluorescence enhanced DOT is a promising non-invasive imaging modality.
- The developed instrumentation facilitates deep tissue examination.
- This technology has potential applications in both small animal research and human screening.
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