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A quasi-analytical method for relaxation rate distribution determination of T2-weighted MRI in brain
Miguel Martín-Landrove1, Giovanni Figueroa, Marco Paluszny
1Centro de Física Molecular y Médica, Escuela de Física, Facultad de Ciencias, Universidad Central de Venezuela, A.P. 47586, Caracas 1041-A, Venezuela. mmartin@fisica.ciens.ucv.ve
Abstract:
A quasi-analytical method for the determination of relaxation rate distribution functions in T2-weighted MRI in brain is proposed. The method solves analytically the set of non linear polynomial equations on the assumption that the transversal magnetization decay in Carr-Purcell-Meiboom-Gill (CPMG) T2-weighted MR brain images can be decomposed in a finite number of exponential decays, each one corresponding to a particular tissue class. The proposed method was validated by numerical simulations and applied to the calculation of relaxation rate distribution functions of tumoral lesions in brain.
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