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Behavioral study of calorie-restricted rats from early old age
1Department of forensic medicine, Laboratory of cell senescence, Medical College of Shantou University, Guangdong, CO 515031, China. yqgeng@126.com
Purpose:
To investigate the effect of Calorie Restriction (CR) on learning and memory ability of early aged rats.
Methods:
18-month rats were subjected to restricted intake by 60% comparing with that of rats fed ad libitum (AL) for 6 months. We compared the overall health status, including survival rate and locomotor activity by open-field test. We examined the spatial cognition ability of the rats by Morris Water Maze.
Results:
Our results showed that CR rats had higher survival rate and spontaneous locomotor activity compared with AL rats. CR rats slowed the inability of spatial learning and reference memory.
Conclusion:
These findings demonstrated that CR in early old rats delayed the declination of spatial cognition.
