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Updated: Jul 10, 2026
07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Measurements of scattering changes using polarization-sensitive optical coherence tomography
Sang-Won Lee1, Jin-Ho Kang, Ji-Yeong Yoo
1Department of Biomedical Engineering, Yonsei University, 234, Maeji, Heungup, Wonju, Gangwon, KOREA.
Summary
Polarization-sensitive optical coherence tomography quantifies scattering changes in turbid media. This technique successfully diagnosed cervical intraepithelial neoplasm (CIN) using Intralipid phantoms.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Ophthalmology
Background:
- Turbid media exhibit scattering that affects light propagation.
- Optical coherence tomography (OCT) is a non-invasive imaging modality.
- Characterizing scattering changes is crucial for understanding tissue properties.
Purpose of the Study:
- To quantify scattering changes in turbid media using PS-OCT.
- To validate the technique with Intralipid phantoms.
- To apply PS-OCT for diagnosing cervical intraepithelial neoplasm (CIN).
Main Methods:
- Utilized polarization-sensitive optical coherence tomography (PS-OCT).
- Measured the degree of circular polarization (DOCP) as a function of depth.
- Employed Intralipid phantoms for experimental validation.
Main Results:
- Demonstrated successful quantification of scattering changes in turbid media.
- Validated the PS-OCT technique using controlled phantom models.
- Achieved successful diagnosis of cervical intraepithelial neoplasm (CIN) with PS-OCT.
Conclusions:
- PS-OCT is effective in quantifying scattering variations within turbid media.
- The developed technique shows promise for non-invasive diagnosis of CIN.
- Further clinical validation of PS-OCT for cervical cancer screening is warranted.
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