Related Experiment Video
Updated: Jul 10, 2026
12:56
Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
Published on: December 19, 2017
In vivo stimulation on rabbit retina using CMOS LSI-based multi-chip flexible stimulator for retinal prosthesis.
T Tokuda1, R Asano, S Sugitani
1Nara Institute Science and Technology, Takayama-cho 8916-5, Ikoma, Nara, 630-0192, JAPAN. tokuda@ms.naist.jp
Summary
Researchers demonstrated a flexible neural stimulator for retinal prostheses in rabbits. The device, implanted in the sclera, successfully evoked electrical responses in the visual cortex, showing feasibility for vision restoration.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Ophthalmology
Background:
- Retinal prostheses aim to restore vision in patients with degenerative retinal diseases.
- Current devices face challenges in flexibility, biocompatibility, and effective neural stimulation.
Purpose of the Study:
- To demonstrate the feasibility of a CMOS LSI-based multi-chip flexible neural stimulator for retinal prosthesis applications.
- To develop and test a novel packaging structure and control system for enhanced device performance.
Main Methods:
- In vivo electrical stimulation experiments were conducted on rabbit retinas.
- A new flexible packaging structure and a comprehensive device control system were developed.
- The multi-chip stimulator was implanted in a suprachoroidal transretinal stimulation (STS) configuration.
- Electrically Evoked Potentials (EEPs) were recorded from the visual cortex.
Main Results:
- The fabricated multi-chip flexible neural stimulator demonstrated successful in vivo functionality.
- The novel packaging and control system facilitated effective device operation.
- Successful elicitation of EEPs in the visual cortex confirmed the stimulator's efficacy.
Conclusions:
- The CMOS LSI-based multi-chip flexible neural stimulator is a feasible technology for retinal prostheses.
- The developed system shows promise for future vision restoration strategies.
- Further research can optimize device design and clinical application for suprachoroidal stimulation.
