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Related Experiment Videos

Using microelectronics technology to communicate with living cells.

F Heer1, S Hafizovic, T Ugniwenko

  • 1Physical Electronics Laboratory, ETH Zurich, Wolfgang-Pauli-Str. 16, 8093 Zurich, Switzerland. fheer@phys.ethz.ch

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 16, 2007
PubMed
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This study presents a 128-electrode complementary metal oxide semiconductor (CMOS) microsystem for bidirectional communication with cultured cells. This chip enables real-time stimulation and recording of neuronal and cardiac cell activity for in vitro research.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Cell Biology

Background:

  • Standard microelectronics face challenges in direct, high-quality interfacing with electrogenic cells.
  • Existing systems often lack integrated signal processing and bidirectional communication capabilities.
  • Need for advanced tools to study complex cellular network dynamics in vitro.

Purpose of the Study:

  • To develop and present a monolithic complementary metal oxide semiconductor (CMOS) microsystem for integrated cell-electronic interfacing.
  • To enable bidirectional communication (stimulation and recording) with cultured electrogenic cells.
  • To facilitate in vitro studies of neural network behavior, plasticity, and responses to stimuli.

Main Methods:

  • Fabrication of a 128-electrode monolithic microsystem using CMOS technology.

Related Experiment Videos

  • Direct use of the chip as a substrate for neuronal and cardiac cell culturing.
  • Integration of per-electrode circuitry for stimulation and signal treatment.
  • On-chip analog-to-digital (A/D) conversion and digital interface for fast data acquisition.
  • Recording of spontaneous and stimulated electrical activity from cell cultures.

    • Main Results:

    • Demonstration of a functional 128-electrode CMOS microsystem for cell culturing.
    • Successful bidirectional communication, including stimulation and high-quality signal recording.
    • Acquisition of spontaneous and stimulated electrical activity data from neuronal and cardiac cell cultures.
    • Validation of on-chip signal processing and digital interface for efficient data transfer.

    Conclusions:

    • The developed CMOS microsystem provides a powerful platform for advanced in vitro electrophysiology.
    • The system facilitates detailed investigation of neural network development, plasticity, and pharmacological effects.
    • This technology enables high-resolution, real-time monitoring and manipulation of cellular electrical activity.