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Dynamical quorum sensing: Population density encoded in cellular dynamics.

Silvia De Monte1, Francesco d'Ovidio, Sune Danø

  • 1Unité Mixte de Recherche 7625, Université Pierre et Marie Curie and Ecole Normale Supérieure, F-75005 Paris, France. demonte@biologie.ens.fr

Proceedings of the National Academy of Sciences of the United States of America
|November 16, 2007
PubMed
Summary
This summary is machine-generated.

Cellular populations synchronize by chemical exchange. This study demonstrates yeast glycolytic oscillations disappear synchronously at low cell density, revealing a quorum-sensing mechanism for collective dynamics.

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Area of Science:

  • Biophysics
  • Systems Biology
  • Cellular Dynamics

Background:

  • Mutual synchronization via chemical exchange drives collective dynamics in cell populations.
  • Existing theories on coherence transitions lack quantitative experimental validation.
  • Cellular oscillations are crucial for understanding population-level behaviors.

Purpose of the Study:

  • To provide a quantitative, experimental demonstration of collective dynamics in cellular populations.
  • To analyze cell-density-dependent glycolytic oscillations in yeast.
  • To elucidate the mechanism behind the disappearance of oscillations at low cell densities.

Main Methods:

  • Modeling and experimental analysis of yeast glycolytic oscillations.
  • Investigating the transition from oscillatory to non-oscillatory states.
  • Analyzing synchronization phenomena at varying cell densities.

Main Results:

  • Observed the disappearance of glycolytic oscillations at low cell densities in yeast.
  • Demonstrated that this disappearance occurs synchronously across all cells.
  • Ruled out desynchronization as the cause for oscillation loss.

Conclusions:

  • Identified a general scenario for the emergence of collective cellular oscillations.
  • Proposed a quorum-sensing mechanism linking cell density to intracellular dynamics.
  • Highlighted the importance of synchronized dynamics in cellular communication.