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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
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Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water

Stefano Avedano1, Lorenzo Tei, Alberto Lombardi

  • 1Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Via Bellini 25/G, I-15100 Alessandria, Italy.

Chemical Communications (Cambridge, England)
|November 16, 2007
PubMed

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In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers energy to a nearby...