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Optimal antibody-radionuclide combinations for clinical radioimmunotherapy: a predictive model based on mouse
E D Yorke1, P L Beaumier, B W Wessels
1Division of Radiation Oncology & Biophysics, George Washington University Medical Center, Washington, DC 20037.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 11, 1991
Abstract:
A theoretical comparison was made of radioimmunotherapy (RIT) dosimetry estimates for eight radionuclides (90Y, 105Rh, 131I, 153Sm, 186Re, 188Re, 198Au, 211At) conjugated to IgG, F(ab')2, and Fab antibody forms. Antibody pharmacokinetics, derived from a nude mouse animal model were combined with appropriate physical data and S values to evaluate absorbed dose to a 0.5 kg centrally located tumor, total body and kidney. Radioimmunoconjugates of F(ab')2 with 90Y, 153Sm and 186Re were predicted to be the most promising for RIT.