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Related Experiment Video

Updated: Jul 10, 2026

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
08:21

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

Published on: February 5, 2016

Aggregation-resistant water-soluble gold nanoparticles.

Layal L Rouhana1, Jad A Jaber, Joseph B Schlenoff

  • 1Department of Chemistry and Biochemistry, Center for Materials Research and Technology (MARTECH), The Florida State University, Tallahassee, Florida 32306, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 17, 2007
PubMed
Summary

Novel zwitterionic disulfide ligands create highly stable, water-soluble gold nanoparticles (Au NPs). These 4 nm Au NPs resist aggregation in high salt concentrations and with polyelectrolytes, showing potential for biomedical applications.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Surface Chemistry

Background:

  • Gold nanoparticles (Au NPs) are crucial in various applications.
  • Achieving stability in biological media remains a challenge for Au NPs.
  • Developing robust capping ligands is key for Au NP applications.

Purpose of the Study:

  • To synthesize stable, water-soluble gold nanoparticles (Au NPs).
  • To functionalize Au NPs with novel zwitterionic disulfide ligands.
  • To evaluate the stability of these modified Au NPs in complex media.

Main Methods:

  • Place exchange reactions for nanoparticle synthesis.
  • Characterization using UV-vis absorption spectroscopy.
  • Analysis of particle size and aggregation via quasi-elastic light scattering.

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Last Updated: Jul 10, 2026

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
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  • Surface-enhanced Raman scattering (SERS) for interaction studies.

    • Main Results:

    • Successfully prepared 4 nm water-soluble gold nanoparticles.
    • Demonstrated remarkable stability in saline solutions up to 3.0 M salt.
    • Observed no precipitation with charged polyelectrolytes or biopolymers, indicating minimal nonspecific interactions.
    • Confirmed stability and association characteristics through spectroscopic and scattering techniques.

    Conclusions:

    • Novel zwitterionic disulfide ligands impart exceptional stability to gold nanoparticles.
    • The developed Au NPs are suitable for use in high ionic strength and complex biological environments.
    • These stable Au NPs hold promise for advanced applications in nanomedicine and diagnostics.