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Changes in body composition, muscle function and energy expenditure after radical cystectomy
Sachin Mathur1, Lindsay D Plank, Andrew G Hill
1Department of Surgery, University of Auckland, Auckland, New Zealand.
BJU International
|November 17, 2007
Summary
Radical cystectomy (RC) leads to significant body protein and water loss in the initial two weeks. While some protein is regained over six months, full recovery of body composition is not achieved, suggesting a need for early nutritional support.
Area of Science:
- Urology
- Metabolic Medicine
- Nutritional Science
Background:
- Radical cystectomy (RC) is a major surgery for bladder cancer.
- Post-surgical recovery involves significant physiological changes.
- Understanding body composition and metabolic shifts after RC is crucial for patient outcomes.
Purpose of the Study:
- To assess changes in body composition, muscle function, and energy expenditure following radical cystectomy (RC).
- To evaluate the recovery trajectory of these parameters at 2 weeks and 6 months post-surgery.
Main Methods:
- Eleven male patients undergoing RC were studied.
- Measurements included total body protein, water, potassium, fat, resting energy expenditure, and muscle strength.
- Data were collected pre-surgery, and at 2 weeks and 6 months post-RC.
Main Results:
- Significant losses in body protein (0.68 kg) and water (3.00 L) occurred within 2 weeks post-RC.
- Resting energy expenditure was elevated by 11% at 2 weeks.
- While 63% of lost protein was regained by 6 months, muscle function returned to baseline.
Conclusions:
- Radical cystectomy results in substantial catabolic loss of body protein that is not fully recovered by 6 months.
- Early nutritional support interventions post-RC may enhance body composition recovery and clinical benefits.
