Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Controlled differentiation of stem cells.

Nathaniel S Hwang1, Shyni Varghese, Jennifer Elisseeff

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Advanced Drug Delivery Reviews
|November 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computing inspired by the brain: a journey from algorithms to organoids.

Nature computational science·2026
Same author

Temporal immunomodulation of CD4<sup>+</sup> T cells by magnesium regulates osteoimmune responses in osteoporotic fracture healing.

Science advances·2026
Same author

Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organs.

Advanced functional materials·2026
Same author

Muscle-to-Bone CX3CL1 Signaling Promotes Skeletal Repair Through CX3CR1+ Osteoprogenitors.

bioRxiv : the preprint server for biology·2026
Same author

A Systematic Review of the Role of Senescent Cells in Uterine Leiomyomas: Deciphering Molecular Pathways and Exploring Therapeutic Prospects.

Reproductive sciences (Thousand Oaks, Calif.)·2026
Same author

Dual-sprayable, multi-functional hydrogel for effective prevention of peritoneal adhesions.

Journal of tissue engineering·2026
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

Biomaterials are crucial for guiding human embryonic stem cell differentiation and expansion in tissue engineering. This review covers recent advances in biomaterial strategies for stem cell differentiation and growth.

Area of Science:

  • Biomaterials Science
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • The extracellular microenvironment significantly influences cellular behavior and stem cell fate.
  • Effective biomaterials are essential for supporting cell attachment, proliferation, and lineage-specific differentiation of human embryonic stem cells (hESCs).
  • Tissue engineering and cellular therapies rely on precise control over stem cell behavior.

Purpose of the Study:

  • To review recent findings on biomaterial strategies for directing hESC differentiation.
  • To discuss established differentiation models for hESCs.
  • To explore various methods for hESC expansion.

Main Methods:

  • Literature review of recent scientific findings and established models.

Related Experiment Videos

  • Analysis of synthetic and naturally-derived biomaterials used in tissue engineering.
  • Examination of growth factors and morphogenetic factors influencing stem cell commitment.

    • Main Results:

    • Biomaterials, alongside biochemical cues, are key in directing hESC differentiation towards specific lineages.
    • Various scaffolding materials have demonstrated efficacy in guiding stem cell differentiation.
    • Established models and emerging strategies for hESC expansion are discussed.

    Conclusions:

    • Appropriate biomaterial selection is critical for successful hESC differentiation and expansion.
    • Advancements in biomaterials offer promising avenues for regenerative medicine and cellular therapies.
    • A comprehensive understanding of differentiation models and expansion strategies is vital for clinical translation.