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Related Experiment Video

Updated: Jul 10, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Thermal-light full-field optical coherence tomography.

L Vabre, A Dubois, A C Boccara

|November 17, 2007

Summary

We developed a high-resolution optical coherence tomography (OCT) system achieving near 1-micrometer resolution in 3D. This breakthrough enables detailed imaging of structures within biological tissues.

Area of Science:

Biomedical optics
Microscopy
Medical imaging

Background:

Optical coherence tomography (OCT) is a valuable non-invasive imaging technique.
Achieving high resolution in OCT is crucial for detailed visualization of microstructures.
Existing OCT systems face limitations in resolution and imaging speed.

Purpose of the Study:

To develop a novel high-resolution optical coherence tomography (OCT) system.
To achieve near-micrometer resolution in three dimensions (3D) for OCT imaging.
To enable realistic volume rendering of biological tissues.

Main Methods:

Utilized a Linnik-type interference microscope as the core OCT system.
Employed a white-light thermal lamp for illumination, ensuring a short coherence length.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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Published on: August 4, 2018

Implemented a parallel detection scheme with a CCD camera for rapid image acquisition.

Main Results:

Achieved a resolution close to 1 micrometer in three dimensions.
Demonstrated OCT imaging with the highest resolution reported to date.
Enabled cross-section (x-y) image acquisition without scanning at rates up to 50 Hz.

Conclusions:

The developed OCT system offers unprecedented 3D resolution.
This high-resolution capability facilitates realistic volume rendering of internal biological structures.
The system represents a significant advancement in OCT imaging technology.