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Related Experiment Videos

[Nevus and malignant cutaneous melanoma].

M M Morales Suárez-Varela1, A Llopis González, M Lacasaña Navarro

  • 1Area de Medicina Preventiva y Salud Pública, Facultad de Farmacia, Universidad de Valencia.

Revista De Sanidad E Higiene Publica
|May 1, 1991
PubMed
Summary

Skin melanoma can develop from various types of moles (naevi). Certain melanoma subtypes, like nodular and superficial spreading melanoma, frequently arise from existing moles. Environmental factors appear more influential than genetics in melanoma development.

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Area of Science:

  • Dermatology
  • Epidemiology
  • Oncology

Background:

  • Epidemiological studies indicate that various types of naevi (moles), including benign, dysplastic, and congenital, can precede malignant skin melanoma (MSM).
  • Understanding the relationship between naevi and melanoma is crucial for early detection and prevention strategies.

Purpose of the Study:

  • To investigate the prevalence of pre-existing naevi in patients diagnosed with malignant skin melanoma.
  • To analyze the association between different types of melanoma and their origin from naevi.
  • To explore the influence of family history and environmental factors on melanoma development.

Main Methods:

  • Retrospective review of clinical histories of 247 malignant skin melanoma cases diagnosed between 1977 and 1987.
  • Statistical analysis using SPSS-PC+ to process variables including prior naevi, family history of neoplasias, and growth types.

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  • Comparison of findings with existing literature, considering geographical and ethnic variations.

    • Main Results:

    • Forty-two percent of patients reported the presence of a naevus lesion prior to the onset of malignant skin melanoma.
    • Malignant nodular melanoma (MNM), superficial spreading melanoma (SSM), and unclassifiable melanoma (UM) were found to originate more frequently from naevi (p < 0.05).
    • Seventy-three percent of patients had no family history of neoplasias, suggesting a stronger influence of environmental factors.

    Conclusions:

    • A significant proportion of malignant skin melanoma cases are associated with pre-existing naevi.
    • Specific melanoma subtypes show a higher propensity to develop from naevi.
    • Environmental factors likely play a more dominant role than genetic predisposition in the etiology of malignant skin melanoma.