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Updated: Jul 10, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[Evidence-based medicine, conceptual challenge or the future of daily practice?]
M Anastasiu1, V Strâmbu, F Popa
1Secţia de Chirurgie, Spitalul Judeţean de Urgenţă Buzău. anastasiu@mail.ols.ro
Abstract:
Evidence based medicine is a recent acquisition concept brought up by its promoters as a new way to learn and practice medicine. Having in view that knowledge access is strongly limited and what seems to be true and argued today may become out-of-date tomorrow, EBM expects to become a methodological base in permanent change. The problem is the patient's option to the medical decision. Who has to decide? Based on what logic or arguments? EBM can't replace the demonstration or the "scientific truth", the statistic studies always being an approximation of reality which can never be reflected in its complexity. That is why, perhaps, Sackett reformulated the definition of EBM as a judicious use of the best medical proof for an individual therapeutic conduct of every patient.
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