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Immunostaining to Visualize Murine Enteric Nervous System Development

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Published on: April 29, 2015

[Intestinal neuronal dysplasia: association with digestive malformations].

R Granero Cendón¹, A Millán López, M J Moya Jiménez

¹Servicio de Cirugía Pediátrica, H. Infantil Universitario Virgen del Rocío, Sevilla. rociogranero3@yahoo.es

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica

|November 21, 2007

Summary

Isolated Intestinal Neuronal Dysplasia type B affects 1 in 7500 newborns, with 35% experiencing associated congenital anomalies, primarily digestive malformations. Familial constipation history was noted in 40% of cases.

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Area of Science:

Gastroenterology
Pediatric Surgery
Pathology

Context:

Isolated Intestinal Neuronal Dysplasia (IND) type B is a condition affecting the enteric nervous system.
Diagnosis involves histopathologic findings like giant ganglia and increased acetylcholinesterase activity.
This study focuses on IND type B not associated with Hirschsprung's disease.

Purpose:

To determine the incidence of congenital malformations in IND type B.
To correlate these anomalies with symptom severity.
To investigate potential familial involvement in IND type B.

Summary:

A retrospective review of 44 IND type B cases (1:7500 newborns) from 1981-2002 was conducted.
35% of patients had associated congenital anomalies, most commonly digestive malformations (20%).
Familial constipation history was present in 40%, and 75% of symptoms appeared in the newborn period.

Impact:

Provides incidence data for congenital anomalies in IND type B.
Highlights the significant association with digestive malformations.
Suggests a potential genetic or familial component requiring further investigation.