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Updated: Jul 10, 2026
07:54
Immunostaining to Visualize Murine Enteric Nervous System Development
Published on: April 29, 2015
[Intestinal neuronal dysplasia: association with digestive malformations]
R Granero Cendón1, A Millán López, M J Moya Jiménez
1Servicio de Cirugía Pediátrica, H. Infantil Universitario Virgen del Rocío, Sevilla. rociogranero3@yahoo.es
Summary
Isolated Intestinal Neuronal Dysplasia type B affects 1 in 7500 newborns, with 35% experiencing associated congenital anomalies, primarily digestive malformations. Familial constipation history was noted in 40% of cases.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Pathology
Context:
- Isolated Intestinal Neuronal Dysplasia (IND) type B is a condition affecting the enteric nervous system.
- Diagnosis involves histopathologic findings like giant ganglia and increased acetylcholinesterase activity.
- This study focuses on IND type B not associated with Hirschsprung's disease.
Purpose:
- To determine the incidence of congenital malformations in IND type B.
- To correlate these anomalies with symptom severity.
- To investigate potential familial involvement in IND type B.
Summary:
- A retrospective review of 44 IND type B cases (1:7500 newborns) from 1981-2002 was conducted.
- 35% of patients had associated congenital anomalies, most commonly digestive malformations (20%).
- Familial constipation history was present in 40%, and 75% of symptoms appeared in the newborn period.
Impact:
- Provides incidence data for congenital anomalies in IND type B.
- Highlights the significant association with digestive malformations.
- Suggests a potential genetic or familial component requiring further investigation.
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