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Updated: Jul 10, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Unlocking the potential of asymmetric hydrogenation at Merck
C Scott Shultz1, Shane W Krska
1Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA. scott_shultz@merck.com
Abstract:
This Account outlines the efforts of Merck scientists toward implementing asymmetric hydrogenation as a core competency within Merck Research Laboratories. Several key factors are discussed including (i) a focus on efficient chemical synthesis, (ii) implementation of high throughput screening (HTS) techniques, (iii) demonstration of robustness on scale, and (iv) diligence to ensure freedom of operation and catalyst supply for manufacturing. Several examples of the development of efficient asymmetric hydrogenation processes are described.
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