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Heparin-induced thrombocytopenia and recent advances in its therapy

Y Hassan1, A Awaisu, N A Aziz

  • 1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. yahaya@usm.my

Journal of Clinical Pharmacy and Therapeutics
|November 21, 2007
PubMed

Insights

Heparin-induced thrombocytopenia (HIT) is a serious condition. Evidence shows alternative anticoagulants like lepirudin and argatroban significantly reduce deaths and complications when heparin is stopped.

Area of Science:

  • Medical Science
  • Hematology
  • Pharmacology

Background:

  • Heparin-induced thrombocytopenia (HIT) is a life-threatening immune-mediated complication of heparin therapy.
  • HIT is associated with substantial morbidity and mortality.
  • Management of HIT presents significant diagnostic and therapeutic challenges.

Purpose of the Study:

  • To critically review the latest evidence on managing heparin-induced thrombocytopenia (HIT).
  • To highlight current therapeutic controversies in HIT management.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE (October 1996 - October 2006).
  • Relevant articles, including reviews, trials, and case reports, were identified and reviewed.
  • Bibliographic citations from identified articles were also examined for pertinent literature.

Main Results:

  • Heparin-induced thrombocytopenia (HIT) is linked to significant patient morbidity and mortality.
  • Stopping heparin is crucial in managing HIT.
  • Alternative anticoagulant therapies, such as lepirudin and argatroban, demonstrate benefit.

Conclusions:

  • An evidence-based approach is essential for managing the complexities of heparin-induced thrombocytopenia (HIT).
  • Alternative anticoagulants like lepirudin and argatroban are beneficial in preventing adverse outcomes in HIT patients.
  • Prompt cessation of heparin and initiation of alternative anticoagulation are recommended.
Abstract

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